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Merck

238900

4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM).

Synonym(s):

4-Cyano-3-methylisoquinoline, PKA Inhibitor XI

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About This Item

Empirical Formula (Hill Notation):
C11H8N2
CAS Number:
161468-32-2
Molecular Weight:
168.19
MDL number:
MFCD02179199
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

4-Cyano-3-methylisoquinoline, A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM).

SMILES string

n1cc2c(c(c1C)C#N)cccc2

InChI

1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3

InChI key

SZWLGBJCLZDZBY-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Product competes with ATP.
Reversible: yes
Target IC50: 30 nM against protein kinase A

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

Other Notes

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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