biological source
human
description
Peptide corresponding to the cell membrane-translocating sequence linked to the single-stranded DNA binding region of human p53, ′peptide 46′, corresponding to amino acids 361-382.
manufacturer/tradename
Upstate®
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Analysis Note
A related p53 activator peptide containing the peptide 46 sequence has been used to induce apoptosis in Ew36, BL41 and SW480 cells1,2. The amount of peptide to be used must be empirically determined.
Application
Peptide corresponding to the cell membrane-translocating sequence linked to the single-stranded DNA binding region of human p53, ′peptide 46′, corresponding to amino acids 361-382 (AAVALLPAVLLALLAP-GSRAHSSHLKSKKGQSTSRHKK). MW = 3932Da. The amount of peptide to be used must be empirically determined.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
MTS Control Peptide (25-003) can be used as a control for experiments with this peptide.
Physical form
lyophilized
Preparation Note
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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A Marchese et al.
The Journal of antimicrobial chemotherapy, 35(1), 53-66 (1995-01-01)
Cefdinir is one of the few oral third generation cephalosporins that shows useful activity against nosocomial Gram-positive pathogens. For this reason the anti-staphylococcal potency of the new drug, alone or in combination with other drugs was further characterized. Against penicillin-resistant
The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.
Selivanova, G, et al.
Nucleic Acids Research, 24, 3560-3567 (1996)
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.
Selivanova, G, et al.
Nature Medicine, 3, 632-638 (1997)
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