Key Documents
biological source
human
description
Peptide corresponding to the cell membrane-translocating sequence linked to the single-stranded DNA binding region of human p53, ′peptide 46′, corresponding to amino acids 361-382.
manufacturer/tradename
Upstate®
NCBI accession no.
UniProt accession no.
shipped in
dry ice
General description
MTS Control Peptide (25-003) can be used as a control for experiments with this peptide.
Application
Peptide corresponding to the cell membrane-translocating sequence linked to the single-stranded DNA binding region of human p53, ′peptide 46′, corresponding to amino acids 361-382 (AAVALLPAVLLALLAP-GSRAHSSHLKSKKGQSTSRHKK). MW = 3932Da. The amount of peptide to be used must be empirically determined.
Physical form
lyophilized
Preparation Note
2 years at -20°C
Analysis Note
A related p53 activator peptide containing the peptide 46 sequence has been used to induce apoptosis in Ew36, BL41 and SW480 cells1,2. The amount of peptide to be used must be empirically determined.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.
Selivanova, G, et al.
Nature Medicine, 3, 632-638 (1997)
A Marchese et al.
The Journal of antimicrobial chemotherapy, 35(1), 53-66 (1995-01-01)
Cefdinir is one of the few oral third generation cephalosporins that shows useful activity against nosocomial Gram-positive pathogens. For this reason the anti-staphylococcal potency of the new drug, alone or in combination with other drugs was further characterized. Against penicillin-resistant
The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.
Selivanova, G, et al.
Nucleic Acids Research, 24, 3560-3567 (1996)
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