Key Documents

View All Documentation

251800

Daunorubicin, Hydrochloride

Name: Daunorubicin, Hydrochloride
Brand: MM

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

Synonym(s):

Daunorubicin, Hydrochloride, Daunomycin, HCl

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₉NO₁₀ · xHCl

CAS Number:

23541-50-6

Molecular Weight:

527.52 (free base basis)

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD04974507

Form:

crystalline solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

form

crystalline solid

potency

≥840 g/kg

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

red

solubility

aqueous buffer: soluble, methanol: soluble, water: soluble

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key

GUGHGUXZJWAIAS-QQYBVWGSSA-N

Description

General description

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
DNA synthesis, RNA synthesis

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.

Other Notes

Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H351,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library