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252750

Deferoxamine Mesylate

Name: Deferoxamine Mesylate
Brand: MM

Iron chelating agent

Synonym(s):

Deferoxamine Mesylate, Desferrioxamine Mesylate, DFOM, Iron Chelator II

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₄₈N₆O₈ · xCH₄O₃S

CAS Number:

138-14-7

Molecular Weight:

560.68 (free base basis)

UNSPSC Code:

41116107

NACRES:

NA.25

MDL number:

MFCD00058605

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Quality Segment

100

description

Merck USA index - 14, 2860

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: chelator

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

faint yellow

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)([O-])C.[N+H3]CCCCCN(O)C(=O)CCC(=O)NCCCCCN(O)C(=O)CCC(=O)NCCCCCN(O)C(=O)C

InChI

1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChI key

IDDIJAWJANBQLJ-UHFFFAOYSA-N

Description

General description

Iron chelating agent. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.

Application

Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol.: This study explores the application of Deferoxamine Mesylate in mitigating iron overload and oxidative stress in neuronal cells, demonstrating its potential in neuroprotection and treatment strategies for neurodegenerative disorders (Wang et al., 2024).

Ferroptosis resists intracellular Vibrio splendidus AJ01 mediated by ferroportin in sea cucumber Apostichopus japonicus.: The study demonstrates the potential of Deferoxamine Mesylate in aquatic animal health, particularly in enhancing the resistance against bacterial infections by modulating ferroptosis pathways (Wang et al., 2024).

Other Notes

Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103.
Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c