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Merck

252801

DGAT-1 Inhibitor, A 922500

The DGAT-1 Inhibitor, A 922500, also referenced under CAS 959122-11-3, controls the biological activity of DGAT-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

DGAT-1 Inhibitor, A 922500

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About This Item

Empirical Formula (Hill Notation):
C26H24N2O4
CAS Number:
959122-11-3
Molecular Weight:
428.48
UNSPSC Code:
12352200

Product Name

DGAT-1 Inhibitor, A 922500, The DGAT-1 Inhibitor, A 922500, also referenced under CAS 959122-11-3, controls the biological activity of DGAT-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

InChI key

BOZRFEQDOFSZBV-DHIUTWEWSA-N

InChI

1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

light yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Disclaimer

Toxicity: Regulatory Review (Z)

General description

An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 µM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 µM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.

Other Notes

King, A.J., et al. 2009. J. Pharmacol. Exp. Ther.330, 526.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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