Skip to Content
Merck

260575

1-Deoxymannojirimycin, Hydrochloride

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Synonym(s):

1-Deoxymannojirimycin, Hydrochloride, DMJ, 1,5-Dideoxy-1,5-imino-D-mannitol, HCl

Sign In to View Organizational & Contract Pricing

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C6H13NO4 · xHCl
CAS Number:
84444-90-6
Molecular Weight:
163.17 (free base basis)
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

ethanol: 1 mg/mL
water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

LXBIFEVIBLOUGU-KVTDHHQDSA-N

General description

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.
Special α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Biochem/physiol Actions

Cell permeable: no
Primary Target
α-mannosidase-I
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 6 months at -20°C.

Other Notes

Suzuki, S.S., and Piette, L.H. 1993. J. Cell. Biochem.51, 181.
Fuhrmann, U., et al. 1984. Nature307, 755.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

U Fuhrmann et al.
Nature, 307(5953), 755-758 (1984-02-23)
Many secretory and membrane proteins are glycoproteins carrying asparagine-linked (N-linked) oligosaccharides. There are two types of N-linked glycans, referred to as high-mannose and complex type, respectively. Biosynthesis of N-linked glycans of the complex type proceeds via a high-mannose intermediate. After
S S Suzuki et al.
Journal of cellular biochemistry, 51(2), 181-189 (1993-02-01)
The mouse embryo fibroblast cell line, C3H/10T1/2, synthesized and deposited a large amount of fibronectin especially in the pericellular matrix. Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service