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Merck

260575

1-Deoxymannojirimycin, Hydrochloride

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Synonym(s):

1-Deoxymannojirimycin, Hydrochloride, DMJ, 1,5-Dideoxy-1,5-imino-D-mannitol, HCl

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About This Item

Empirical Formula (Hill Notation):
C6H13NO4 · xHCl
CAS Number:
84444-90-6
Molecular Weight:
163.17 (free base basis)
UNSPSC Code:
12352200
Assay:
≥98% (TLC)
Form:
crystalline solid
Quality level:
100
Storage condition:
OK to freeze
desiccated (hygroscopic)

Key Documents

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Product Name

1-Deoxymannojirimycin, Hydrochloride, A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

InChI key

LXBIFEVIBLOUGU-KVTDHHQDSA-N

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

ethanol: 1 mg/mL
water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
α-mannosidase-I
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Harmful (C)

General description

A specific α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.
Special α-mannosidase I inhibitor that blocks conversion of high mannose to complex oligosaccharides.

Other Notes

Suzuki, S.S., and Piette, L.H. 1993. J. Cell. Biochem.51, 181.
Fuhrmann, U., et al. 1984. Nature307, 755.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S S Suzuki et al.
Journal of cellular biochemistry, 51(2), 181-189 (1993-02-01)
The mouse embryo fibroblast cell line, C3H/10T1/2, synthesized and deposited a large amount of fibronectin especially in the pericellular matrix. Confluent cultures of these cells cultured in the presence of 0.3 micrograms/ml of retinyl acetate released cell surface fibronectin and
U Fuhrmann et al.
Nature, 307(5953), 755-758 (1984-02-23)
Many secretory and membrane proteins are glycoproteins carrying asparagine-linked (N-linked) oligosaccharides. There are two types of N-linked glycans, referred to as high-mannose and complex type, respectively. Biosynthesis of N-linked glycans of the complex type proceeds via a high-mannose intermediate. After

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