260960
DNA-PK Inhibitor
The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
DNA-PK Inhibitor, DMNB, 4,5- Di methoxy-2- nitro benzaldehyde, DNA-Dependent Protein Kinase Inhibitor, DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C9H9NO5
CAS Number:
Molecular Weight:
211.17
UNSPSC Code:
12352100
NACRES:
NA.77
MDL number:
Quality Level
assay
≥90% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
bright yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[N+](=O)([O-])c1c(cc(c(c1)OC)OC)C=O
InChI
1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3
InChI key
YWSPWKXREVSQCA-UHFFFAOYSA-N
General description
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120 ). Does not affect PKC or Chk2 kinase activities.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
DNA-PK activity
DNA-PK activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15 µM against DNA-PK (DNA-dependent protein kinase) activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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