264151
Caspase-3 Substrate VII, Fluorogenic
Fluorogenic caspase-3 substrate.
Synonym(s):
Caspase-3 Substrate VII, Fluorogenic, Ac-DEVD-AFC
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About This Item
Empirical Formula (Hill Notation):
C30H34F3N5O13
Molecular Weight:
729.61
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
Quality Level
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
DMSO: 5 mg/mL
fluorescence
λex ~400 nm, λem ~505 nm
shipped in
ambient
storage temp.
−20°C
General description
Fluorogenic caspase-3 substrate (excitation maximum: ~400 nm; emission maximum: ~505 nm). Also acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10.
Fluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
Biochem/physiol Actions
Reversible: no
Cell permeable: no
Primary Target
Fluorogenic caspase-3 substrate
Fluorogenic caspase-3 substrate
Product does not compete with ATP.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-Asp-Glu-Val-Asp-AFC
Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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