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264158

Caspase Modulator II, 1541B

Caspase Modulator II, 1541B primarily used in Inhibition.

Synonym(s):

Caspase Modulator II, 1541B, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI, Procaspase-3 Activator III, Procaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI

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About This Item

Empirical Formula (Hill Notation):
C23H15N3O4
Molecular Weight:
397.38
NACRES:
NA.54
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 1.8 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable, of 8-Hydroxy 1541 (Cat. No. 529662) analog that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective as simultaneous activations of caspase-3/-6 in cell death induction of the cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
A cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662 ) that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Wolan, D.W., et al. 2009. Science326, 853.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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