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Key Documents

286888

Sigma-Aldrich

BHQ

Mobilizes Ca2+ specifically from Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity.

Synonym(s):

BHQ, 2,5-Di-( t-butyl)-1,4-hydroquinone, t-BuBHQ, 2,5-Di-(t-butyl)-1,4-hydroquinone, t-BuBHQ

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About This Item

Empirical Formula (Hill Notation):
C14H22O2
CAS Number:
88-58-4
Molecular Weight:
222.32
MDL number:
MFCD00008825
UNSPSC Code:
12352200

Quality Level

100

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mM
ethanol: 25 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C14H22O2/c1-13(2,3)9-7-12(16)10(8-11(9)15)14(4,5)6/h7-8,15-16H,1-6H3

InChI key

JZODKRWQWUWGCD-UHFFFAOYSA-N

General description

Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.

Biochem/physiol Actions

Cell permeable: no
Primary Target
micosomal and sarcoplasmic reticulation Ca2+ ATPase activity
Product does not compete with ATP.
Reversible: no

Other Notes

Salvador, J.M., and Mata, A.M. 1998. Arch. Biochem. Biophys. 351, 272.
Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540.
Khan, Y.M., et al. 1995. Biochemistry 34, 14385.
Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118.
Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167.
Schilling, W.P., et al. 1992. Biochem. J.284, 521.
Wictome, M., et al. 1992. FEBS Lett.304, 109.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.
Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H317,H335,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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