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Merck

300270

PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline

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About This Item

Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
129075-73-6
Molecular Weight:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01866274

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SMILES string

N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2

InChI

1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)

InChI key

RVOUDNBEIXGHJY-UHFFFAOYSA-N

assay

≥90% (HPLC)

form

solid

potency

40 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Other Notes

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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