300270
PARP Inhibitor III, DPQ
The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
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About This Item
Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
Molecular Weight:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥90% (HPLC)
form
solid
potency
40 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
InChI
1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI key
RVOUDNBEIXGHJY-UHFFFAOYSA-N
General description
A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Other Notes
Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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