309795
DIDS disodium salt
≥85% (HPLC), solid, anion transport inhibitor, Calbiochem®
Synonym(s):
DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
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About This Item
Empirical Formula (Hill Notation):
C16H8N2O6S4 · 2Na
CAS Number:
Molecular Weight:
498.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥85% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Product Name
DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
Quality Segment
assay
≥85% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
yellow
solubility
water: 0.5%
shipped in
ambient
storage temp.
−20°C
SMILES string
[S](=O)(=O)(O)c1c(ccc(c1)N=C=S)\C=C\c2c(cc(cc2)N=C=S)[S](=O)(=O)O
InChI
1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+
InChI key
YSCNMFDFYJUPEF-OWOJBTEDSA-N
General description
Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cl- uptake
Cl- uptake
Product does not compete with ATP.
Reversible: no
Target IC50: 150 nM inhibiting Cl- uptake in neuroblastoma cells
Other Notes
Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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