317505
1,2-Dioctanoyl-sn-glycerol
Cell-permeable activator of protein kinase C (PKC).
Synonym(s):
1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV
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About This Item
Empirical Formula (Hill Notation):
C19H36O5
CAS Number:
Molecular Weight:
344.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
description
RTECS - RH0764500
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
clear colorless
solubility
chloroform: soluble, ethyl acetate: soluble
shipped in
wet ice
storage temp.
−70°C
SMILES string
O([C@H](COC(=O)CCCCCCC)CO)C(=O)CCCCCCC
InChI
1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
InChI key
ZQBULZYTDGUSSK-KRWDZBQOSA-N
General description
Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKCα than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Protein kinase C
Protein kinase C
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Unstable in solution; reconstitute just prior to use.
Analysis Note
Single spot by TLC
Other Notes
Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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