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Merck

317700

Dkk-1 Inhibitor, WAY-262611, HCl

The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

Synonym(s):

Dkk-1 Inhibitor, WAY-262611, HCl, (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI

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About This Item

Empirical Formula (Hill Notation):
C20H22N4 · xHCl
Molecular Weight:
318.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200

Key Documents

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Product Name

Dkk-1 Inhibitor, WAY-262611, HCl, The Dkk-1 Inhibitor, WAY-262611 controls the biological activity of Dkk-1.

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

General description

A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.

Other Notes

Pelletier, J.C., et al. 2009. J. Med. Chem.52, 6962.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Yifan Wu et al.
Immunity, 54(11), 2595-2610 (2021-09-11)
Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly understood. Here, we leverage wild-type and mutant Candida albicans to determine how this

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