322337
Dvl-PDZ Domain Inhibitor, Peptide Pen-N3
The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Dvl-PDZ Domain Inhibitor, Peptide Pen-N3, Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH2, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III, Wnt Pathway Inhibitor III, Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH2, Dishevelled PDZ Domain Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C163H256N48O37S
Molecular Weight:
3512.14
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC50 = 11 µM) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂
Zhang, Y., et al. 2009. Nat. Chem. Biol.5, 217.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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