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COA/COQ

322337

Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

Name: Dvl-PDZ Domain Inhibitor, Peptide Pen-N3
Brand: MM

The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Dvl-PDZ Domain Inhibitor, Peptide Pen-N3, Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH₂, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III, Wnt Pathway Inhibitor III, Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH₂, Dishevelled PDZ Domain Inhibitor

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About This Item

Empirical Formula (Hill Notation):

C₁₆₃H₂₅₆N₄₈O₃₇S

Molecular Weight:

3512.14

UNSPSC Code:

12352200

Quality Level

100

Assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC₅₀ = 11 µM) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂

Zhang, Y., et al. 2009. Nat. Chem. Biol.5, 217.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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