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Merck

324745

Elastase Inhibitor III

The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Elastase Inhibitor III, HLE Inhibitor, MeOSuc-AAPV-CMK

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About This Item

Empirical Formula (Hill Notation):
C22H35ClN4O7
Molecular Weight:
502.99
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
desiccated

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Product Name

Elastase Inhibitor III, The Elastase Inhibitor III controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 10 mg/mL
methanol: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Human leukocyte elastase (HLE)
Product does not compete with ATP.
Reversible: no
Target Ki: 10 µM against human leukocyte elastase (HLE)

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent inhibitor of human leukocyte elastase (HLE) (Ki = 10 µM).
A potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki = 10 µM). Protects against lung injury induced by instillation of elastase.

Other Notes

Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis.141, 672.
Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.
Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.
MeOSuc-Ala-Ala-Pro-Val-CMK

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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