324761
Elastase Inhibitor V
Synonym(s):
Elastase Inhibitor V, 2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
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About This Item
Empirical Formula (Hill Notation):
C14H7BrClNO2
Molecular Weight:
336.57
NACRES:
NA.54
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
off-white
solubility
DMSO: 50 mg/mL (Use only fresh DMSO.)
shipped in
ambient
storage temp.
2-8°C
General description
A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Elastase
Elastase
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Hsieh, P.W., et al. 2010. Eur. J. Med. Chem.45, 3111.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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