324761
Elastase Inhibitor V
Synonym(s):
Elastase Inhibitor V, 2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
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About This Item
Empirical Formula (Hill Notation):
C14H7BrClNO2
Molecular Weight:
336.57
NACRES:
NA.54
UNSPSC Code:
12352200
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
protect from light
color
off-white
solubility
DMSO: 50 mg/mL (Use only fresh DMSO.)
shipped in
ambient
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Elastase
Elastase
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).
Other Notes
Hsieh, P.W., et al. 2010. Eur. J. Med. Chem.45, 3111.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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