324895
eIF-2α Inhibitor, Salubrinal
eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.
Synonym(s):
eIF-2α Inhibitor, Salubrinal, Sal
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About This Item
Empirical Formula (Hill Notation):
C21H17Cl3N4OS
CAS Number:
Molecular Weight:
479.81
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
elF-2α
elF-2α
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM preventing HSV replication both in Vero cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Boyce, M., et al. 2005. Science307, 935.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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YongYao Xu et al.
PloS one, 17(7), e0271656-e0271656 (2022-07-29)
Inflammatory signaling induces barrier dysfunction in retinal-pigmented epithelium (RPE) cells and plays a role in the pathology of age-related macular degeneration (AMD). We studied the role of Zn flux from the endoplasmic reticulum (ER) to the cytoplasm via Zip7 during
Ziwei Zhang et al.
Molecular nutrition & food research, 66(5), e2100791-e2100791 (2021-12-31)
To investigate the role of endoplasmic reticulum stress (ERS)-induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L. (POL) extract, a medicinal herb with anti-inflammatory, antioxidant, immune-regulating, and antitumor properties, in vitro and in vivo.
Ting Zhu et al.
Veterinary research, 52(1), 148-148 (2021-12-22)
Viruses have evolved multiple strategies to manipulate their host's translational machinery for the synthesis of viral proteins. A common viral target is the alpha subunit of eukaryotic initiation factor 2 (eIF2α). In this study, we show that global protein synthesis