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Merck

325885

c-MET, GST-Fusion, Human, Recombinant, S. frugiperda

c-MET, GST-Fusion, Human, Recombinant (aa 956-1390) fused at the N-terminus to a GST-His6-thrombin cleavage site and expressed in S. frugiperda. c-Met is a receptor tyrosine kinase activated by HGF.

Synonym(s):

Hepatocyte growth factor receptor tyrosine kinase

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About This Item

NACRES:
NA.77
UNSPSC Code:
12352202

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Product Name

c-MET, GST-Fusion, Human, Recombinant, S. frugiperda, c-MET, GST-Fusion, Human, Recombinant (aa 956-1390) fused at the N-terminus to a GST-His6-thrombin cleavage site and expressed in S. frugiperda. c-Met is a receptor tyrosine kinase activated by HGF.

recombinant

expressed in baculovirus infected Sf21 cells

form

liquid

specific activity

≥30 units/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

Recombinant, human MET (amino acids 956-1390) (Genebank entry NM_000245) fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed in S. frugiperda insect cells using a baculovirus expression system. c-Met is a receptor tyrosine kinase activated by hepatocyte growth factor (HGF)/scatter factor (SF). MET is a plasminogen-like protein thought to be a humoral mediator of liver regeneration.
Recombinant, human c-MET (amino acids 956-1390) (Genebank entry NM_000245) fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed in S. frugiperda insect cells using a baculovirus expression system. c-Met is a receptor tyrosine kinase activated by hepatocyte growth factor (HGF)/scatter factor (SF). c-MET is a plasminogen-like protein thought to be a humoral mediator of liver regeneration.

Other Notes

One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Ala, Glu, Lys, Tyr)6:2:5:1 per min at 30°C, using variable concentrations of ATP (0.1-1.48 µM).
Palka, H.L., et al. 2003. J. Biol. Chem.278, 5278.
Vadnais, J., et al. 2002. J. Biol. Chem.277, 48342.
Crostella, L., et al. 2001. Oncogene20, 3735.
Guiton, M., et al. 1994. J. Biol. Chem269, 30370.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol, pH 8.0.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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