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Merck

328500

ERO1 Inhibitor I, Erodoxin

The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.

Synonym(s):

ERO1 Inhibitor I, Erodoxin, 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C7H5BrN2O5
CAS Number:
181995-71-1
Molecular Weight:
277.03
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
MFCD00624873

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InChI

1S/C7H5BrN2O5/c1-15-7-2-4(8)5(9(11)12)3-6(7)10(13)14/h2-3H,1H3

InChI key

SYWWRIKZBWQUGY-UHFFFAOYSA-N

SMILES string

BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL (Use only fresh DMSO)

shipped in

wet ice

Quality Level

100

Related Categories

General description

A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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