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Merck

341249

FAAH Inhibitor II

The FAAH Inhibitor II, also referenced under CAS 546141-08-6, controls the biological activity of FAAH. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Synonym(s):

FAAH Inhibitor II, URB597, Cyclohexylcarbamic acid-3ʹ-carbamoyl-biphenyl-3-yl Ester, 3ʹ-Carbamoyl-biphenyl-3-yl-cyclohexylcarbamate

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About This Item

Empirical Formula (Hill Notation):
C20H22N2O3
CAS Number:
546141-08-6
Molecular Weight:
338.40
UNSPSC Code:
12352200
MDL number:
MFCD05863934

Key Documents

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Product Name

FAAH Inhibitor II, The FAAH Inhibitor II, also referenced under CAS 546141-08-6, controls the biological activity of FAAH. This small molecule/inhibitor is primarily used for Cell Signaling applications.

InChI

1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)

InChI key

ROFVXGGUISEHAM-UHFFFAOYSA-N

assay

≥98% (NMR)

form

crystalline solid

manufacturer/tradename

Calbiochem®

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

OK to freeze
protect from light

color

white

solubility

ethanol: 1 mg/mL
DMF: 10 mg/mL
DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Other Notes

Kathuria, S., et al. 2003. Nat. Med.9, 76.
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Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot, purge with an inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: yes
Primary Target
FAAH
Product does not compete with ATP.
Reversible: no
Target IC50: 4.6 nM against FAAH

Disclaimer

Toxicity: Toxic (F)

General description

A cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 >30 µM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). It also does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 >100 µM), as well as several ion-channels and neurotransmitter transporters.
A cell-permeable, carbamate compound that acts as a potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.6 nM in brain membranes). Shown to block anandamide (Cat. No. 172100) breakdown in rat cortical neurons (IC50 = 0.5 nM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases, namely, AchE (acetyl cholinesterase) (IC50 >100 µM), BCh (butyryl cholinesterase) (IC50 >100 µM), and MGL (monoglyceride lipase) (IC50 >30 µM). Does not interfere with the binding of anandamide to cannabinoid receptors, CB1 and CB2 (IC50 >100 µM), several ion-channels, or neurotransmitter transporters.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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Mireia Casasampere et al.
Journal of lipid research, 65(3), 100520-100520 (2024-02-19)
Lipid amidases of therapeutic relevance include acid ceramidase (AC), N-acylethanolamine-hydrolyzing acid amidase, and fatty acid amide hydrolase (FAAH). Although fluorogenic substrates have been developed for the three enzymes and high-throughput methods for screening have been reported, a platform for the

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