Factor I, Human

Name: Factor I, Human
Brand: MM

Factor I, Human, is a glycoprotein composed of two non-identical disulfide-bonded subunits of 50 and 38 kDa. A serine protease that requires protein cofactor in order to effect substrate cleavage.

Synonym(s):

C3b/C4b Inactivator

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About This Item

NACRES:

NA.25

UNSPSC Code:

12352202

Product Name

Factor I, Human, Factor I, Human, is a glycoprotein composed of two non-identical disulfide-bonded subunits of 50 and 38 kDa. A serine protease that requires protein cofactor in order to effect substrate cleavage.

form

liquid

assay

≥95% (SDS-PAGE)

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin, trace

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Toxicity: Standard Handling (A)

General description

Native factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (α) and 38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.

Other Notes

Solol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In PBS, pH 7.2.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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