Fibrinogen, Bovine Plasma

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homogeneous by SDS-PAGE.

Toxicity: Harmful (C)

Do not disturb until the fibrinogen is completely solubilized.

Native fibrinogen from bovine plasma. A plasma glycoprotein synthesized and secreted by hepatic parenchymal cells. Fibrinogen, also known as Coagulation Factor I, is an acute-phase plasma protein found at a concentration of about 300 mg/100 ml. Conversion of soluble fibrinogen to the insoluble clot-forming fibrin is the terminal stage of blood clotting. Clinically, fibrinogen is elevated in pregnancy, after surgical trauma, and myocardial infarction, and is decreased in cases of liver cirrhosis and serum hepatitis.

Native fibrinogen from bovine plasma. An acute phase plasma glycoprotein synthesized and secreted by hepatic parenchymal cells. Contains ≥ 95% clottable proteins.

Lyophilized from 20 mM sodium citrate-HCl, pH 7.4.

Following reconstitution, aliquot and freeze (-20°C) for long term storage or store at room temperature (20°C) for short term storage. Do not store solutions on ice; precipitation will occur. Stock solutions are stable for up to 4 h at 20°C or for up to 6 months at -20°C.

Solutions used to reconstitute fibrinogen should first be brought to 37°C. Once at 37°C, the solution can be added to the fibrinogen and this mixture should remain at 37°C until the fibrinogen is completely solubilized.