341598
Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem
The Fibroblast Growth Factor-2 Inhibitor, NSC37204 controls the biological activity of Fibroblast Growth Factor-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem
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About This Item
Empirical Formula (Hill Notation):
C21H14N2Na2O9S2
Molecular Weight:
548.45
UNSPSC Code:
12352200
assay
>95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
brown
solubility
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ± 6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ± 5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ± 2 (FGF-2 + NSC37203).
A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
Other Notes
Colombo, G., et al. 2010. J. Biol. Chem.285, 8733.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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