344041
cFMS Receptor Tyrosine Kinase Inhibitor
InSolution, ≥95%
Synonym(s):
InSolution cFMS Receptor Tyrosine Kinase Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C20H22N4O3
Molecular Weight:
366.41
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
liquid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo.
Packaging
Packaged under inert gas
Physical form
A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344036) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA102, 16078.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - (refers to pure substance)
flash_point_c
87 °C - closed cup - (refers to pure substance)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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