FSB

Name: FSB
Brand: MM

A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

Synonym(s):

FSB, (E,E)-1-Fluoro-2,5- bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₇FO₆

CAS Number:

760988-03-2

Molecular Weight:

420.39

MDL number:

MFCD28902305

UNSPSC Code:

41105331

NACRES:

NA.25

Product Name

FSB, A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

InChI key

DZXZHGCGNRRJEG-WMWQKROPSA-N

SMILES string

Fc1c(ccc(c1)\C=C\c3cc(c(cc3)O)C(=O)O)\C=C\c2cc(c(cc2)O)C(=O)O

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Detection Substrates & Enzymes

Proteins & Enzymes

Protein Biology

Biochem/physiol Actions

Cell permeable: no

Primary Target
Amyloidophilic fluorescent probe

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.

This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.

Other Notes

Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c