344150
FPT Inhibitor I
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
FPT Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C19H29NO6P · 3Na
Molecular Weight:
467.38
UNSPSC Code:
12352200
Assay:
≥85% (NMR)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
assay
≥85% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: ≥10 mg/mL
shipped in
ambient
storage temp.
−70°C
General description
A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 83 nM). Inhibits geranylgeranyltransferase I (IC50 = 26 µM) and II (IC50 = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.
Biochem/physiol Actions
Primary Target
Farnesyltransferase (Ftase)
Farnesyltransferase (Ftase)
Product does not compete with ATP.
Target IC50: 83 nM against Ftase
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 4 months at -70°C.
Other Notes
Manne, V., et al. 1995. Drug Development Res.34, 121.
Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.
Patel, D.V., et al. 1995. J. Med. Chem.38, 2906.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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