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Merck

344580

FtsZ Polymer Stabilizer, PC190723

Synonym(s):

FtsZ Polymer Stabilizer, PC190723, 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer

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About This Item

Empirical Formula (Hill Notation):
C14H8ClF2N3O2S
Molecular Weight:
355.75
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

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assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

tan

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 μg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
FtsZ
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Elsen, N. L., et al. 2012. J. Am. Chem. Soc.134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem.285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem.75, 7946.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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