Glucose Transporter Inhibitor III, STF-31

Name: Glucose Transporter Inhibitor III, STF-31
Brand: MM

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Synonym(s):

Glucose Transporter Inhibitor III, STF-31, STF-31

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₅N₃O₃S

Molecular Weight:

423.53

MDL number:

MFCD04153828

UNSPSC Code:

12352200

NACRES:

NA.77

Quality Level

100

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C

InChI key

NGQPRVWTFNBUHA-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

General description

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)