361547
GSK-3β Inhibitor VI
The GSK-3β Inhibitor VI, also referenced under CAS 62673-69-2, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
GSK-3β Inhibitor VI, 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
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About This Item
Empirical Formula (Hill Notation):
C6H3Br2ClOS
CAS Number:
Molecular Weight:
318.41
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
ethanol: 1 mg/mL, DMSO: 5 mg/mL (Use fresh, anhydrous DMSO only.)
shipped in
wet ice
storage temp.
−20°C
InChI
1S/C6H3Br2ClOS/c7-3-1-5(4(10)2-9)11-6(3)8/h1H,2H2
InChI key
KYVDGDMQERQKOY-UHFFFAOYSA-N
General description
A cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
A thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 1 µM against Gsk-3β
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
Other Notes
Conde, S., et al. 2003. J. Med. Chem.46, 4631.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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