368620
Group III Caspase Inhibitor I
The Group III Caspase Inhibitor I controls the biological activity of Group III caspases (caspase-6, -8, -9, and -10). This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Group III Caspase Inhibitor I, Z-AE(OMe)VD(OMe)-FMK
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About This Item
Empirical Formula (Hill Notation):
C28H39FN4O10
Molecular Weight:
610.63
UNSPSC Code:
12352200
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
DMSO: 20 mM
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspases-6, -8, -9, and -10), although more effective towards caspases -6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Analysis Note
Single spot by TLC
Other Notes
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Z-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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