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Merck

368620

Group III Caspase Inhibitor I

The Group III Caspase Inhibitor I controls the biological activity of Group III caspases (caspase-6, -8, -9, and -10). This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Group III Caspase Inhibitor I, Z-AE(OMe)VD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C28H39FN4O10
Molecular Weight:
610.63
UNSPSC Code:
12352200

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Product Name

Group III Caspase Inhibitor I, The Group III Caspase Inhibitor I controls the biological activity of Group III caspases (caspase-6, -8, -9, and -10). This small molecule/inhibitor is primarily used for Cancer applications.

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 20 mM

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Analysis Note

Single spot by TLC

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1, caspase-3, caspase-6, caspase-8, caspase-9, caspase-10
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspases-6, -8, -9, and -10), although more effective towards caspases -6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Z-Ala-Glu(OMe)-Val-Asp(OMe)-CH₂F*

Preparation Note

Following reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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