Key Documents

View All Documentation

370625

Guanabenz Acetate

Name: Guanabenz Acetate
Brand: MM

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.

Synonym(s):

Guanabenz Acetate, 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₈H₈Cl₂N₄ · xC₂H₄O₂

CAS Number:

23256-50-0

Molecular Weight:

231.08 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00153801

Assay:

≥99% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1c(c(ccc1)Cl)\C=N\N=C(\[N+H3])/N.[O-]C(=O)C

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

InChI key

MCSPBPXATWBACD-GAYQJXMFSA-N

Description

General description

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC₅₀ ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c