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Merck

370677

Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

Synonym(s):

Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt, Rp-8- pCPT-cGMPS, TEA, PKG Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C16H15ClN5O6PS2 · xC6H15N
Molecular Weight:
503.88 (free acid basis)
NACRES:
NA.77
UNSPSC Code:
41106305
Assay:
≥99% (HPLC)
Form:
lyophilized
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)

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assay

≥99% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

solubility

water: 0.5 mg/mL, DMSO: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.
A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKG1α
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498.
Lee, S.J., et al. 1996. Dev. Biol.180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Willmott, N., et al. 1996. J. Biol. Chem.271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

Legal Information

Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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