370690
Z-Guggulsterone
A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels.
Synonym(s):
Z-Guggulsterone, GS, trans-, trans-4,17(20)-Pregnadiene-3,16-dione
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About This Item
Empirical Formula (Hill Notation):
C21H28O2
Molecular Weight:
312.45
UNSPSC Code:
12352200
Form:
solid
Storage condition:
OK to freeze
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Farnesoid X receptor (FXR)
Farnesoid X receptor (FXR)
Product does not compete with ATP.
Reversible: no
Target IC50: 10 µM as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation in the presence of 100 µM chenodeoxycholic acid
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Analysis Note
Single spot by TLC
Other Notes
Cui, J., et al. 2003. J. Biol. Chem.278, 10214.
Urizar, N.L., et al. 2002. Science296, 1703; Chander, R., et al. 1996. Phytotherapy Res.10, 508.
Urizar, N.L., et al. 2002. Science296, 1703; Chander, R., et al. 1996. Phytotherapy Res.10, 508.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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