HBDDE

Name: HBDDE
Brand: MM

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

Synonym(s):

HBDDE, 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈O₈

CAS Number:

154675-18-0

Molecular Weight:

338.31

MDL number:

MFCD00925616

UNSPSC Code:

12352200

NACRES:

NA.77

Product Name

HBDDE, A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

SMILES string

O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C

InChI

1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3

InChI key

NEBCAMAQXZIVRE-UHFFFAOYSA-N

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

orange

solubility

ethanol: 1 mg/mL
warm water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKCα

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 43 µM against PKCα

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, β_I, and β_II isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.

Protein kinase C (PKC) inhibitor. Selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, βI and βII isozymes.

Other Notes

Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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