373277
Hh Signaling Antagonist XI, MRT-14
The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Synonym(s):
Hh Signaling Antagonist XI, MRT-14
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About This Item
Empirical Formula (Hill Notation):
C24H23N3O6
CAS Number:
Molecular Weight:
449.46
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(NC(NC1=CC(NC(C2=CC=CC=C2)=O)=CC=C1)=O)C3=CC(OC)=C(C(OC)=C3)OC
General description
A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803 ) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Manetti, F., et al. 2010. Mol. Pharmacol.78, 658.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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