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Merck

377980

Hispidin

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM).

Synonym(s):

Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Empirical Formula (Hill Notation):
C13H10O5
CAS Number:
555-55-5
Molecular Weight:
246.22
UNSPSC Code:
12352200
MDL number:
MFCD01866972
Assay:
≥90% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+

InChI key

QISBNGLMCHHHFG-HNQUOIGGSA-N

assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKCβ
Product does not compete with ATP.
Reversible: yes
Target IC50: 2 µM against PKCβ

Disclaimer

Toxicity: Standard Handling (A)

General description

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Other Notes

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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