385880
Hsp25 Kinase Inhibitor
The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Hsp25 Kinase Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor, MAPKAP Kinase-2 Inhibitor, MK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C61H113N21O16
Molecular Weight:
1396.68
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Level
assay
≥98% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
DMSO: soluble, water: soluble
shipped in
ambient
storage temp.
−20°C
General description
A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]
Biochem/physiol Actions
Cell permeable: yes
Primary Target
(Hsp25) kinase
(Hsp25) kinase
Product does not compete with ATP.
Reversible: no
Target Ki: 8.1 µM against (Hsp25) kinase
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Other Notes
H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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