400086
HIF Inhibitor VI
The HIF-1 Inhibitor, NSC-134754 controls the biological activity of HIF-1. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
HIF Inhibitor VI, NSC-134754
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C27H34N2O2
Molecular Weight:
418.57
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
brown
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
Packaging
Packaged under inert gas
Other Notes
Chau, N.M., et al. 2005. Cancer Res.65, 4918.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.