401251
IM-412
IM-412 primarily used in Inhibition.
Synonym(s):
IM-412, 3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, TGF beta Inhibitor, IM-412
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About This Item
Empirical Formula (Hill Notation):
C16H14ClN5O2
Molecular Weight:
343.77
NACRES:
NA.32
UNSPSC Code:
12352200
Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 3 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50 of 4.1 µM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Park, S., et al. 2010. Biochem. Biophy. Res. Comm.399, 268.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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