IκB Kinase Inactive Control Peptide, Cell-Permeable

Name: IκB Kinase Inactive Control Peptide, Cell-Permeable
Brand: MM

An inactive control for IκB Kinase Inhibitor Peptide.

Synonym(s):

IκB Kinase Inactive Control Peptide, Cell-Permeable, Ac- AAVALLPAVLLALLAPDDRHD AGLD AMKDE-NH₂

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About This Item

Empirical Formula (Hill Notation):

C₁₃₈H₂₂₉N₃₇O₄₃S

Molecular Weight:

3126.58

NACRES:

NA.77

UNSPSC Code:

12352202

Product Name

IκB Kinase Inactive Control Peptide, Cell-Permeable, An inactive control for IκB Kinase Inhibitor Peptide.

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white to white

solubility

water: 1 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Cell permeable: no

Primary Target
An inactive control for IκB Kinase Inhibitor Peptide

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

An inactive control for IκB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IκB (Ser³²→Ala and Ser³⁶→Ala) fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.

An inactive control for IkB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IkB (Ser³² → Ala and Ser³⁶ → Ala), linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.

Other Notes

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂

Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO J.14, 2876.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c