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Merck

401488

IKK-3 Inhibitor IX

The IKK-3 Inhibitor IX, also referenced under CAS 862812-98-4, controls the biological activity of IKK-3. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

IKK-3 Inhibitor IX, 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile

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About This Item

Empirical Formula (Hill Notation):
C22H19N3O5S2
CAS Number:
862812-98-4
Molecular Weight:
469.53
UNSPSC Code:
12352200

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Product Name

IKK-3 Inhibitor IX, The IKK-3 Inhibitor IX, also referenced under CAS 862812-98-4, controls the biological activity of IKK-3. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

InChI key

LDTAHRLHGHFHKP-UHFFFAOYSA-N

InChI

1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

beige

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
IKK-3
Product competes with ATP.
Reversible: no
Target IC50: 40 nM against IKK-3 (IKK-ε)

Disclaimer

Toxicity: Harmful (C)

General description

A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50<50 µM) 1A2, 2D6, 2C9, and 3A4.

Other Notes

Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett.16, 6236.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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