Skip to Content
Merck

401491

IKK Inhibitor XII

The IKK Inhibitor XII, also referenced under CAS 928655-63-4, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

IKK Inhibitor XII

Sign In to View Organizational & Contract Pricing.

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H16ClN3O3S
CAS Number:
928655-63-4
Molecular Weight:
401.87
UNSPSC Code:
12352200

Product Name

IKK Inhibitor XII, The IKK Inhibitor XII, also referenced under CAS 928655-63-4, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable amino-diarylbenzamide compound that acts as a potent ATP site-targeting inhibitor against IKK-1 and IKK-2 (pIC50 = 6.4 and 7.0, respectively), while exhibiting more than 50-fold less potency toward a panel of greater than 50 other kinases, including IKK-3 (pIC50<4.8), ALK5, Cdk-2, EGFR, ErbB2, GSK-3β, Plk1, Src, and VEGFR-2. Shown to effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC50 = 6.1, 6.4, and 5.7, respectively) as well as TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC50 = 5.7).

Other Notes

Christopher, J.A., et al. 2007. Bioorg. Med. Chem. Lett.17, 3972.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

So Eun Youn et al.
International journal of molecular sciences, 23(19) (2022-10-15)
PAUF, a tumor-promoting protein secreted by cancer cells, exerts paracrine effects on immune cells through TLR4 receptors expressed on immune cell surfaces. This study aimed to investigate if PAUF elicits autocrine effects on pancreatic cancer (PC) cells through TLR4, a
A frequent SNP in TRIM5I? strongly enhances the innate immune response against LINE-1 elements.
Lagisquet, et al.
Frontiers in Immunology, 14, 1168589-1168589 (2023)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service