401491
IKK Inhibitor XII
The IKK Inhibitor XII, also referenced under CAS 928655-63-4, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Synonym(s):
IKK Inhibitor XII
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About This Item
Empirical Formula (Hill Notation):
C19H16ClN3O3S
CAS Number:
Molecular Weight:
401.87
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable amino-diarylbenzamide compound that acts as a potent ATP site-targeting inhibitor against IKK-1 and IKK-2 (pIC50 = 6.4 and 7.0, respectively), while exhibiting more than 50-fold less potency toward a panel of greater than 50 other kinases, including IKK-3 (pIC50<4.8), ALK5, Cdk-2, EGFR, ErbB2, GSK-3β, Plk1, Src, and VEGFR-2. Shown to effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC50 = 6.1, 6.4, and 5.7, respectively) as well as TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC50 = 5.7).
Packaging
Packaged under inert gas
Other Notes
Christopher, J.A., et al. 2007. Bioorg. Med. Chem. Lett.17, 3972.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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