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Merck

407141

D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem

A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3].

Synonym(s):

D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem, Bt3(1,3,5)IP3/AM

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About This Item

Empirical Formula (Hill Notation):
C36H57O30P3
Molecular Weight:
1062.74
UNSPSC Code:
12352211

Key Documents

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assay

≥98% (HPLC)

form

syrup

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

clear

solubility

DMSO: 100 mM (IPx), DMSO: 100 mg/mL (PLURONIC® F-127 detergent)

shipped in

ambient

storage temp.

−20°C

Biochem/physiol Actions

Cell permeable: yes
Primary Target
A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3]
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3].
Note: Each set contains 1 µmol Bt3(1,3,5)IP3/AM and 10 mg PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.
Novel analogs capable of exhibiting Ins(1,4,5)P3-like agonist or antagonist effects on calcium release are more resistant to hydrolysis and metabolic degradation than IP3 or IP4. Consequently, they can produce a prolonged activation of cellular processes dependent on the Ins(1,4,5)P3 receptor interaction. These tools are important in the elucidation of the molecular interactions of Ins(1,4,5)P3 with its intracellular receptor and with Ins(1,4,5)P3-kinase and 5-phosphatase. Acetoxymethyl esters of inositol phosphate are highly lipophilic. Hence, they easily diffuse through the cell membrane. Note: Each set contains 1 µmol of Bt3(1,3,5)IP3/AM and 10 mg of PLURONIC® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.

Other Notes

Rudolf, M.T., et al. 2003. Bioorg. Med. Chem.11, 3315.

Packaging

Packaged under inert gas

Physical form

1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC® F-127 detergent.

Preparation Note

Following reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Pluronic is a registered trademark of BASF

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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