Key Documents

COA/COQ

407621

IL-2Rα Antagonist

Name: IL-2Rα Antagonist
Brand: MM

The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.

Synonym(s):

IL-2Rα Antagonist, (R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₀N₄O₃ · xC₂HF₃O₂

CAS Number:

1217448-66-2

Molecular Weight:

446.54 (free base basis)

MDL number:

MFCD08703086

UNSPSC Code:

12352200

NACRES:

NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

ethanol: 2 mg/mL
DMSO: 28 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)O.N1(C[C@H](CCC1)CC(=O)N[C@@H](Cc2ccc(cc2)C#Cc3ccccc3)C(=O)OC)\C(=N\[H])\N

InChI

1S/C26H30N4O3.C2HF3O2/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19;3-2(4,5)1(6)7/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31);(H,6,7)/t22-,23+;/m1./s1

InChI key

BVMWPONRCOSTMK-RFPXDPOKSA-N

General description

A non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC₅₀ = 3 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibitor of the IL-2/IL-2Rα interaction

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3 µM against IL-2/IL-2Rα interaction

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Emerson, S.D., et al. 2003. Protein Science12, 811.
Tilley, J.W., et al. 1997. J. Am. Chem. Soc.119, 7589.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)