407709
Insulin, Zinc, Human, Recombinant, P. pastoris
Synonym(s):
Insulin, Zinc, Human, Recombinant, P. pastoris
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About This Item
Biological source:
yeast (Pichia pastoris)
Form:
solid
Assay:
≥95—105%
biological source
yeast (Pichia pastoris)
Quality Level
description
Merck USA index - 14, 4980
sterility
non-sterile
assay
≥95—105%
form
solid
specific activity
≥25 IU/mg (dry basis)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
<10 EU/mg Endotoxin (EU/mg protein)
color
white to off-white
solubility
0.01 M HCl: soluble
shipped in
wet ice
storage temp.
−20°C
InChI key
PBGKTOXHQIOBKM-FHFVDXKLSA-N
General description
Recombinant, human insulin (zinc) expressed in P. pastoris. Peptide anabolic hormone produced by pancreatic β-cells. Increases the synthesis of protein, fat, glycogen, and substrate oxidation in mitochondria. Interacts with membrane insulin receptor to cause its biological actions.
Preparation Note
Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
Insulin is practically insoluble from pH 4.5-7.0.
Other Notes
Mohan, C., et al. 1989. Curr. Topics Cell. Reg.30, 105.
Johnson, I.S. 1983. Science219, 632.
Johnson, I.S. 1983. Science219, 632.
≥25 IU/mg (dry basis).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
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Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Yamini Yadav et al.
The FEBS journal, 289(23), 7561-7581 (2022-07-11)
PP2Cα is one of the newly identified isoforms of metal-dependent protein phosphatases (PPM). The role of this phosphatase in neuronal insulin signalling is completely unknown. In the present study, we show insulin-mediated rapid upregulation of a protein of the insulin
Mohan Sreelekshmi et al.
Journal of biochemical and molecular toxicology, 35(6), 1-8 (2021-03-03)
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the