407715
Interleukin-13, Human, Recombinant, E. coli
Synonym(s):
Interleukin-13, Human, Recombinant, E. coli, rhIL-13
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About This Item
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
<1.0 EU/μg Endotoxin (EU/μg IL-13)
shipped in
ambient
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
ED₅₀ = 0.5-2.5 ng/ml as measured in a cell proliferation assay using a human factor-dependent cell line, TF-1
Disclaimer
Toxicity: Standard Handling (A)
General description
Recombinant, human interleukin-13 expressed in E. coli. Pleiotropic cytokine that shares many of the properties of IL-4. Exhibits IL-4-like activities on monocytes/macrophages and human B cells but has no effect on T cells. A potent regulator of STAT6 and JAK3 in NK and T cells. Regulates inflammatory and immune responses. Inhibits inducible nitric oxide synthase in human mesangial cells.
Other Notes
Yu, C.R., et al. 1998. J. Immunol. 161, 218.
Saura, M., et al. 1996. Biochem. J. 313, 641.
Xi, X., et al. 1995. Br. J. Haematol. 90, 921.
Zurawski, G., and DeVries, J.E. 1994. Stem Cells 12, 169.
McKenzie, A.N.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3735.
Minty, A., et al. 1993. Nature 362, 248.
Saura, M., et al. 1996. Biochem. J. 313, 641.
Xi, X., et al. 1995. Br. J. Haematol. 90, 921.
Zurawski, G., and DeVries, J.E. 1994. Stem Cells 12, 169.
McKenzie, A.N.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3735.
Minty, A., et al. 1993. Nature 362, 248.
Physical form
Lyophilized from sterile-filtered PBS, pH 7.4.
Preparation Note
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to a concentration of ≥5 µg/ml with sterile PBS.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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