420122

JAK3 Inhibitor V

Name: JAK3 Inhibitor V
Brand: MM

The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JAK3 Inhibitor V, (2-Naphthylvinyl Ketone), ZM 449829

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₀O

CAS Number:

4452-06-6

Molecular Weight:

182.22

UNSPSC Code:

12352200

Quality Level

100

Assay

≥98% (HPLC)

form

waxy solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated
protect from light

color

white

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2

InChI key

FOTCGZPFSUWZBN-UHFFFAOYSA-N

General description

A breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC₅₀ = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.

A breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC₅₀ = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.

Other Notes

Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett.10, 575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)