420133
JNK Inhibitor VI, TI-JIP153-163 - Calbiochem
The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
JNK Inhibitor VI, TI-JIP153-163 - Calbiochem
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C61H104N20O14
Molecular Weight:
1341.60
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Kd in low µM range
Primary Target
JNK
JNK
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
Other Notes
Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.
H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service