420141
JAK2 Inhibitor V, Z3
The JAK2 Inhibitor V, Z3, also referenced under CAS 195371-52-9, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
JAK2 Inhibitor V, Z3, 2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
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About This Item
Empirical Formula (Hill Notation):
C23H24N2O
CAS Number:
Molecular Weight:
344.45
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
oil
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥97% (HPLC)
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
colorless
solubility
DMSO: 10 mg/mL, ethanol: 10 mg/mL
shipped in
wet ice
storage temp.
2-8°C
InChI
1S/C23H24N2O/c1-23(15-13-20-11-5-7-17-24-20,16-14-21-12-6-8-18-25-21)22(26)19-9-3-2-4-10-19/h2-12,17-18H,13-16H2,1H3
InChI key
SETYDCSRABYHSW-UHFFFAOYSA-N
General description
A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 µM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays. Z3 suppresses the Jak2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sayyah, J., et al. 2008. Mol. Cancer Ther.7, 2308.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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